| Type | MGI:General | Description | on a regular chow diet, the plasma levels of cholesteryl esters (CE) and HDL cholesterol in mutant mice are reduced to 7% and 14%, respectively, of C57BL/6 control mice; in contrast, non-HDL cholesterol levels remain unaffected on a HF/HC diet, the plasma levels of CE and HDL cholesterol are decreased to 44% and 6%, respectively, of C57BL/6 control mice; non-HDL cholesterol levels are reduced to 52% of control levels notably, homozygotes fed the atherogenic diet show a dramatic increase in the CE/total cholesterol ratio from 21 to 76% relative to control mice on the HF/HC, homozygotes show an increase in the mean diameter of the small spherical particles in the HDL size range; also, the % of discoidal particles in the HDL fraction decreases from 14 to 4% after the HF/HC diet |
