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Comment :

Type  MGI:General Description  at E17.5, some intervertebral disks (IVDs) are compressed relative to wild-type, but at this age, size of IVDs are same as wild-type at 8 weeks, nucleus pulposus is dislocated to periphery of IVD in homozygotes with kinked and normal-appearing tails from caudal vertebrae 5 to 25, irregular boundary with direct contact between the nucleus pulposus the annulus fibrosus, compared to sharp boundary seen in wild-type