| Type | MGI:General | Description | 76% of MEFs exhibit supernumerary centrioles; ectopic centrioles show normal 9-fold symmetry but are unpaired, unlike wild-type paired centrioles supernumerary centrioles associate with multiple centrosomal proteins with normal stoichiometry, suggesting that they form functional centrosomes surprisingly, MEFs exhibit multiple mother centrioles, suggesting additional defects in centriole maturation and identity |
