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Publication : Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion.

First Author  Mann EA Year  1997
Journal  Biochem Biophys Res Commun Volume  239
Issue  2 Pages  463-6
PubMed ID  9344852 Mgi Jnum  J:43682
Mgi Id  MGI:1098343 Doi  10.1006/bbrc.1997.7487
Citation  Mann EA, et al. (1997) Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion. Biochem Biophys Res Commun 239(2):463-6
abstractText  Heat-stable enterotoxin (STa) is an important causative agent of diarrheal disease throughout the world. STa is known to bind specifically to receptors in the intestine, provoking intense intestinal secretion. Binding of STa, or of the mammalian endogenous ligands guanylin and uroguanylin, activates the guanylyl cyclase C receptor (GC-C); the resulting elevation of cGMP levels stimulates chloride secretion via CFTR. We have generated knockout mice which completely lack the GC-C receptor. These mice are viable and show no obvious alteration in intestinal fluidity. However, GC-C null mice are refractory to the secretory action of STa, proving that the GC-C receptor is necessary for the diarrheal response induced by STa. Copyright 1997 Academic Press.
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