| Type | MGI:General | Description | mutants start to show lower weight at 2 months of age mutants treated with Dox to turn off transgene expression from conception to 3 months of age show normal weight Dox administration from 1 to 3 months of age to turn off transgene expression before the onset of abnormalities is seen does not prevent abnormal phenotypes, with mutants developing lower weight from 9 weeks of age Dox administration from 3 to 5 months of age to turn off transgene expression after the onset of abnormal phenotypes does not result in recovery after 2 months of Dox treatment |
