| Type | MGI:General | Description | mice develop Sjogren's syndrome by 4 weeks of age, with females being more susceptible and presenting earlier onset of the disease than males mice show T cell-dominant immune cell infiltration in the salivary glands at 4 weeks and a gradual increase in the frequency of B cells, and an increase in anti-SSA and anti-SSB antibodies around 8 weeks of age transfer or T cells from mutant cervical lymph nodes, but not spleen, is sufficient to induce the development of Sjogren's syndrome in RAG2 null mice 3-day-old mice transferred with Treg cells derived from mature wild-type spleen show improved xerostomia, although saliva production is still reduced, a lesser degree of lymphocyte infiltration into salivary glands is seen and mice are protected against development of Sjogren's syndrome mice develop lupus nephritis |
