| Type | MGI:General | Description | in a neonatal hypoxic-ischemic brain injury model, hemizygous males show markedly increased neuron apoptosis in the hippocampi ipsi-lateral to the common carotid artery ligation relative to wild-type controls after treatment with tunicamycin, cultured primary cortical neurons isolated from E16.5 mutant embryos show increased neuronal death relative to wild-type neurons after transient exposure to potassium cyanide/2-deoxyglucose followed by recovery (to mimic ischemia-reperfusion injury in culture), mutant cortical neurons show a significant increase in cell death relative to wild-type neurons |
