| Type | MGI:General | Description | in vitro, mutant aortic rings cultured in Matrigel form significantly fewer vessel sprouts and fewer branches per sprout than control rings; treatment of mutant aortic rings with the NOS substrate l-arginine restores the number of vessel sprouts to control levels, whereas d-arginine has no effect on vessel growth in vivo, new vessel growth is reduced in a Matrigel plug assay, as determined by the presence of dextran staining in excised plugs in a physiological setting, capillary density in adipose tissue is reduced both basally (on a normal diet) and after high-fat diet-induced adipose expansion |
