| Type | MGI:General | Description | mice infected with the Daniels strain of Theilers murine encephalomyelitis virus (TMEV) develop an acute CNS disease similar to infected wild-type mice, showing similar incidence of seizures, and amounts of inflammation and neural death in the CNS, however they do not resolve the infection as in wild-type mice and develop Theilers murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) with severe inflammatory demyelinating lesions in the spinal cord 2-3 months after infection inflammatory cells of TMEV-infected mice are primarily mononuclear cells (MNCs) and the majority of inflammatory cells in the spinal cord are CD3+ TMEV-infected mice have more viral RNA in the CNS than wild-type mice at 1 week post infection |
