mice are susceptible to infection with SARS-CoV-2 USA-WA1/2020 strain, losing over 20% of their initial body weight, are lethargic with rough fur and hunched appearance, immobile and do not eat or drink and succumb to infection by 2 dpi with SARS-CoV-2, mice show presence of virus in nasal turbinate and in lungs; viral titers at the nasal turbinates are maintained, but decrease in the lung by 4 dpi by 4 dpi with SARS-CoV-2, virus is detected in the brain, with levels increasing at 6 dpi
