| Type | MGI:General | Description | islets show nearly undetectable mitochondrial electron transport chain complex CII activity, elevated succinate levels, increase in protein lysine succinylation and increase in expression of the dessucinylation enzyme SIRT5 islets show reduced basal and glucose-stimulated respiration and reduced maximal respiration and spare reserve capacity islets show a more than 50% reduction in ATP synthase-related oxygen consumption rate following oligomycin injection glucose-exposed islets fail to increase the ATP to ADP ratio islets show accumulation of succinate, with no change in fumarate levels, fatty acid intermediates, nucleic acid building blocks and precursors of protein synthesis despite a deficit of free amino acid pool |
