| Type | MGI:General | Description | mice show increased sensitivity to dextran sulfate sodium (DSS)-induced colitis with more extensive weight loss, higher disease activity index (DAI), shorter colons, greater myeloperoxidase (MPO) activity, histopathological scores and infiltration of F4/80+ macrophages, increased cell apoptosis, and lower cell proliferation than DSS-treated wild-type controls moreover, colonic protein levels of phosphorylated p65 and mature caspase-1 as well as colonic expression of proinflammatory cytokines (IL-1beta and IL-6) are higher than in DSS-treated wild-type controls, indicating exacerbated activation of NF-kappaB signaling and Nlrp3 inflammasome during DSS treatment, mice show a more extensive reduction in colonic Nr1d1 (Rev-erbalpha) expression than wild-type controls |
