| Type | MGI:General | Description | mice treated with tamoxifen on days 1 to 3 after birth then injected with diethylnitrosamine (DEN) 14 days later to induce hepatic carcinogenesis and fed a high-fat diet show a decrease in liver tumor number, average tumor size and maximum tumor size compared with controls, indicating decreased susceptibility to DEN-induced tumorigenesis on a high-fat diet tumor regions show increased hepatocyte apoptosis and a greater accumulation of macrophages than in controls |
