| First Author | Mauvieux L | Year | 2001 |
| Journal | Eur J Immunol | Volume | 31 |
| Issue | 7 | Pages | 2080-6 |
| PubMed ID | 11449361 | Mgi Jnum | J:70403 |
| Mgi Id | MGI:2137163 | Doi | 10.1002/1521-4141(200107)31:7<2080::aid-immu2080>3.0.co;2-h |
| Citation | Mauvieux L, et al. (2001) T early alpha (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence. Eur J Immunol 31(7):2080-6 |
| abstractText | Both TCRA alleles are rearranged in mature T lymphocytes, as a result of a lack of allelic exclusion at the TRCA locus. We show in a series of T cell clones that the two TCRJA segments are not randomly, but rather coincidentally, rearranged in a given T cell. The TCRJA coincidence relies, in part, on the presence of 'T early alpha' (TEA), a cis-regulatory genetic element located upstream of the TCRJA cluster. TEA promotes specific recombinational accessibility that targets primary TCRVAJA rearrangements on the 5' side of the TCRA locus. In a model of multiple waves of TCRVAJA recombination, this cis-regulatory effect of TEA allows for the scanning of the entire TCRJA cluster, thereby increasing the TCR alpha/beta diversity potential. |
