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Publication : Atlantic salmon (Salmo salar L.) skin contains a novel kininogen and another cysteine proteinase inhibitor.

First Author  Ylönen A Year  1999
Journal  Eur J Biochem Volume  266
Issue  3 Pages  1066-72
PubMed ID  10583403 Mgi Jnum  J:59012
Mgi Id  MGI:1350778 Doi  10.1046/j.1432-1327.1999.00950.x
Citation  Ylonen A, et al. (1999) Atlantic salmon (Salmo salar L.) skin contains a novel kininogen and another cysteine proteinase inhibitor. Eur J Biochem 266(3):1066-72
abstractText  We describe the purification and characterization of two novel cysteine proteinase inhibitors found in Atlantic salmon skin. One of these, salmon kininogen, has a molecular mass of 52 kDa as determined by matrix-assisted laser desorption/ionization time-of-flight MS, is multiply charged with pI values of 4.0, 4.2 and 4.6 and shows homology to kininogens including the bradykinin motif. The other, salarin, has a molecular weight of 43 kDa, a pI of 5.1 and shows weak homology to cysteine proteinases. Both proteins are N- and O-glycosylated and inhibit papain and ficin but not trypsin.
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