| First Author | Salier JP | Year | 2000 |
| Journal | Biochim Biophys Acta | Volume | 1482 |
| Issue | 1-2 | Pages | 25-34 |
| PubMed ID | 11058744 | Mgi Jnum | J:65861 |
| Mgi Id | MGI:1927392 | Doi | 10.1016/s0167-4838(00)00144-8 |
| Citation | Salier J (2000) Chromosomal location, exon/intron organization and evolution of lipocalin genes. Biochim Biophys Acta 1482(1-2):25-34 |
| abstractText | Lipocalins exhibit low sequence similarity that contrasts with a tightly conserved folding shared by all members of this superfamily. This conserved folding can be, at least partly, accounted for by a highly conserved gene structure. The array of lipocalin genes that have so far been studied mostly in mammals indicate a large conservation of a typical seven exon/six intron arrangement. Other conserved features include a partly coding exon 1 of variable size, fixed sizes of exons 2-5 that code for an array of lipocalin-specific beta-strands and a tendency of the last exons to either fuse or expand into further exons without major changes in the length of the resulting open reading frame. The conserved exon/intron arrangement as well as a clustering of most lipocalin genes in given chromosomes of human and mouse indicate that the lipocalin genes diverged from a shared ancestor by successive rounds of duplications followed by late changes in exon arrangements. |
