| First Author | Killian JK | Year | 2000 |
| Journal | Mol Cell | Volume | 5 |
| Issue | 4 | Pages | 707-16 |
| PubMed ID | 10882106 | Mgi Jnum | J:61841 |
| Mgi Id | MGI:1355643 | Doi | 10.1016/s1097-2765(00)80249-x |
| Citation | Killian JK, et al. (2000) M6P/IGF2R imprinting evolution in mammals. Mol Cell 5(4):707-16 |
| abstractText | Imprinted gene identification in animals has been limited to eutherian mammals, suggesting a significant role for intrauterine fetal development in the evolution of imprinting. We report herein that M6P/IGF2R is not imprinted in monotremes and does not encode for a receptor that binds IGF2. In contrast, M6P/IGF2R is imprinted in a didelphid marsupial, the opossum, but it strikingly lacks the differentially methylated CpG island in intron 2 postulated to be involved in imprint control. Thus, invasive placentation and gestational fetal growth are not required for imprinted genes to evolve. Unless there was convergent evolution of M6P/ IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes. |
