| First Author | Bonneville M | Year | 1989 |
| Journal | Nature | Volume | 342 |
| Issue | 6252 | Pages | 931-4 |
| PubMed ID | 2480528 | Mgi Jnum | J:26181 |
| Mgi Id | MGI:73846 | Doi | 10.1038/342931a0 |
| Citation | Bonneville M, et al. (1989) Blockage of alpha beta T-cell development by TCR gamma delta transgenes. Nature 342(6252):931-4 |
| abstractText | T lymphocytes recognize antigens by means of T-cell receptors (TCR) composed of alpha beta or gamma delta heterodimers. The mechanism governing the development of alpha beta- and gamma delta-bearing T cells from a common precursor T cell is so far unknown. It has been proposed that T-cell precursors rearrange their gamma- and delta-chain genes first, and alpha beta T cells are generated only from those cells that fail to rearrange productively both gamma- and delta-chain genes. Our recent study on gamma delta-transgenic mice contradicted this hypothesis, however, and indicated that repression of gamma-chain gene expression mediated by a transcriptional silencer element has a critical role in the generation of alpha beta T cells. Here we report that the generation of alpha beta T cells is severely blocked in transgenic mice carrying gamma- and delta-chain transgenes without the associated silencer, thereby strengthening the validity of the silencer model of T-cell development. |
