| First Author | König A | Year | 2000 |
| Journal | Mech Dev | Volume | 93 |
| Issue | 1-2 | Pages | 211-4 |
| PubMed ID | 10781959 | Mgi Jnum | J:62106 |
| Mgi Id | MGI:1858341 | Doi | 10.1016/s0925-4773(00)00266-5 |
| Citation | Konig A, et al. (2000) The HMG-box transcription factor XTcf-4 demarcates the forebrain-midbrain boundary. Mech Dev 93(1-2):211-4 |
| abstractText | A small subfamily of HMG-box transcription factors, the LEF/TCF group, serves as nuclear transducer of the Wnt-1/Wg signaling cascade. Upon Wnt-1/Wg signaling their members interact with beta-catenin and regulate the expression of Xenopus target genes siamois, twin, nodal related-3 or fibronectin. We have isolated a new HMG-box transcription factor in Xenopus that will be addressed XTcf-4 based on its homology to human and murine Tcf-4. Unlike XTcf-3, which is a maternal gene, and XLef-1 that is expressed after mid blastula transition (Molenaar et al., 1998. Mech. Dev. 75, 151-154), XTcf-4 expression starts at late neurula stage and is restricted to the anterior most midbrain demarcating the forebrain-midbrain boundary. The expression partially overlaps with a broad set of Xenopus Wnt family members in distinct patterns. XTcf-4 transcripts were also found partially co-localized with those of Xaxin, an intracellular antagonist of Wnt-1/Wg signaling. |
