| First Author | Young CR | Year | 1976 |
| Journal | J Immunogenet | Volume | 3 |
| Issue | 3 | Pages | 199-205 |
| PubMed ID | 965768 | Mgi Jnum | J:23439 |
| Mgi Id | MGI:71137 | Doi | 10.1111/j.1744-313x.1976.tb00573.x |
| Citation | Young CR, et al. (1976) Genetic control of the immune response to ferritin in mice. J Immunogenet 3(3):199-205 |
| abstractText | The immune response to the antigen horse spleen ferritin was tested in sixteen inbred strains of mice. Using a fixed antigen percentage bound isotope technique, it was found that the quantity of antibody produced was related to the genetic status of the responding animal. A continuous distribution of responses was obtained, which were found to be linked to H-2 loci and the 2 non-H-2 loci 'Tla' and 'Theta' and these responses are detectable following primary immunization. It is suggested that the continuous distribution of quantitative antibody responses to ferritin, is compatible either with a large number of IR-genes or with a cross tolerance hypothesis requiring no IR-genes at all. |
