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Publication : Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2.

First Author  Meruelo D Year  1977
Journal  J Exp Med Volume  146
Issue  4 Pages  1079-87
PubMed ID  197195 Mgi Jnum  J:5863
Mgi Id  MGI:54340 Doi  10.1084/jem.146.4.1079
Citation  Meruelo D, et al. (1977) Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2. J Exp Med 146(4):1079-87
abstractText  Resistance to radiation leukemia virus-induced leukemogenesis is associated with the H-2D region of the H-2 complex, or with closely linked loci. The H-2Dd allele confers resistance ot the disease, while the H-2D-Q and H-2Ds alleles are associated with susceptibility. It is not clear whether Ir genes, or an alternative mechanism are responsible for the observed H-2-linked resistance to the disease.
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