| First Author | Brodeur PH | Year | 1984 |
| Journal | Eur J Immunol | Volume | 14 |
| Issue | 10 | Pages | 922-30 |
| PubMed ID | 6092095 | Mgi Jnum | J:7612 |
| Mgi Id | MGI:56081 | Doi | 10.1002/eji.1830141012 |
| Citation | Brodeur PH, et al. (1984) The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes. Eur J Immunol 14(10):922-30 |
| abstractText | Seven families of Igh-V genes have been defined by Southern blot analysis of genomic DNA from eighteen inbred strains of mice. Each of twenty-four cloned Vh genes hybridized to one of seven nonoverlapping sets of Eco RI restriction fragments. These families contain from 2 to approximately 40 hybridizing fragments. From these data we estimate that the mouse Igh-V locus consists of one hundred Vh genes. Genes within a Vh family share greater than 80% sequence homology while the sequence homology between families is generally less than 70%. There is extensive restriction fragment length polymorphism among the strains analyzed allowing the assignment of complete (Igh-V + Igh-C) Igh haplotypes for eighteen inbred mouse strains. |
