| First Author | Yagüe J | Year | 1985 |
| Journal | Cell | Volume | 42 |
| Issue | 1 | Pages | 81-7 |
| PubMed ID | 2410143 | Mgi Jnum | J:7926 |
| Mgi Id | MGI:56395 | Doi | 10.1016/s0092-8674(85)80103-3 |
| Citation | Yague J, et al. (1985) The T cell receptor: the alpha and beta chains define idiotype, and antigen and MHC specificity. Cell 42(1):81-7 |
| abstractText | Three independent T cell hybridomas were isolated that have identical specificities for antigen and products of the major histocompatibility complex (MHC). All three react with the same clone-specific antireceptor antibody, and Southern blots show all three contain the same rearranged alpha and beta genes. Variants of one of these hybridomas, DO-11.10, were isolated that had lost the ability to respond to antigen plus MHC. These proved to have lost the DO-11.10-specific alpha or beta genes or both. Fusion of alpha-loss variants to beta-loss variants restored reactivity. These results indicate that the specific recognition of antigen plus MHC is determined solely by the alpha/beta-containing T cell receptor. |
