| First Author | Brown MA | Year | 1987 |
| Journal | Cell | Volume | 50 |
| Issue | 5 | Pages | 809-18 |
| PubMed ID | 3497723 | Mgi Jnum | J:8816 |
| Mgi Id | MGI:57281 | Doi | 10.1016/0092-8674(87)90339-4 |
| Citation | Brown MA, et al. (1987) B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell 50(5):809-18 |
| abstractText | BSF-1/interleukin-4, a product of activated T cells, has multiple biological activities that affect cells of most hematopoietic lineages. Among these is the ability of BSF-1 to costimulate the growth of mast cells and regulate the production of IgE. We demonstrate here that BSF-1 mRNA is expressed by a majority of transformed mast cell lines and by 5 IL-3-dependent non-transformed mast cell lines. BSF-1 activity, including the ability to enhance the growth of IL-3-dependent mast cells, was detected in the supernatants of transformed mast cells. The role of BSF-1 as a mast cell growth factor, its constitutive production by transformed mast cells, and the lack of IL-3 production by most of these cells raise the possibility that BSF-1 may act as an autocrine growth factor for some transformed mast cells. Furthermore, production of BSF-1 mRNA by nontransformed cells indicates that mast cells may be an important physiologic source of this factor. |
