| First Author | Cochran BH | Year | 1984 |
| Journal | Science | Volume | 226 |
| Issue | 4678 | Pages | 1080-2 |
| PubMed ID | 6093261 | Mgi Jnum | J:20706 |
| Mgi Id | MGI:68781 | Doi | 10.1126/science.6093261 |
| Citation | Cochran BH, et al. (1984) Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor [published erratum appears in Science 1986 Apr 18;232(4748):307]. Science 226(4678):1080-2 |
| abstractText | Complementary DNA clones of genes induced by platelet-derived growth factor (PDGF) in BALB/c-3T3 cells were isolated; one such clone contains a domain having nucleotide sequence homology with the third exon of c-fos. This nucleotide sequence homology is reflected in the predicted amino acid sequences of the gene products. Under low stringency conditions, the mouse v-fos gene cross-hybridizes with the PDGF-inducible complementary DNA clone. However, the messenger RNA transcripts of mouse c-fos and the new fos-related gene can be distinguished by gel electrophoresis and by S1 nuclease analysis. Expression of the authentic c-fos gene is induced by PDGF and superinduced by the combination of PDGF and cycloheximide. |
