| First Author | Beynon RJ | Year | 1983 |
| Journal | Science | Volume | 219 |
| Issue | 4590 | Pages | 1351-3 |
| PubMed ID | 6338590 | Mgi Jnum | J:24821 |
| Mgi Id | MGI:72532 | Doi | 10.1126/science.6338590 |
| Citation | Beynon RJ, et al. (1983) Deficiency of a kidney metalloproteinase activity in inbred mouse strains. Science 219(4590):1351-3 |
| abstractText | Kidneys from BALB/c mice contain a potent metalloendoproteinase, termed meprin, that is active against large proteins as well as small peptides. The enzyme is present in mouse strains C57BR/cdJ, C57BL/6J, BALB/cJ, A/J, DBA/IJ, CD/l, Swiss, and ICR. Three related inbred strains, CBA/J, CBA/CaJ, and C3H/He, are markedly deficient in this enzymatic activity. This is the first report of a heritable deficiency of an intracellular proteinase in mammalian tissues. Meprin deficiency appears to have arisen as an early event in the development of the C stock. Furthermore, meprin is present in the progeny of a cross between a meprin-sufficient female (C57BL/6) and a meprin-deficient male (C3H/HeN), an indication that the trait for the deficiency is recessive. |
