| First Author | Isackson PJ | Year | 1987 |
| Journal | Biochemistry | Volume | 26 |
| Issue | 8 | Pages | 2082-5 |
| PubMed ID | 3304419 | Mgi Jnum | J:32335 |
| Mgi Id | MGI:79835 | Doi | 10.1021/bi00382a003 |
| Citation | Isackson PJ, et al. (1987) Epidermal growth factor binding protein: identification of a different protein. Biochemistry 26(8):2082-5 |
| abstractText | Partial amino acid sequence analysis of epidermal growth factor binding protein (EGF-BP), an arginine esteropeptidase that specifically associates with EGF to form a high molecular weight complex in male mouse submandibular glands, has revealed a single, distinct protein that is different from three previously reported forms of EGF-BP. This protein shows substantial sequence homology with these other putative forms of EGF-BP as well as with a large family of kallikreins expressed in the mouse submandibular gland. Purified EGF-BP contains three polypeptide chains as a result of two internal cleavages at residues 87-88 and 140-141. These modifications may represent processing events that are critical for determining the binding specificity of EGF-BP, since they occur within regions surrounding the substrate binding site. |
