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Publication : The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor.

First Author  Siu G Year  1984
Journal  Nature Volume  311
Issue  5984 Pages  344-50
PubMed ID  6090932 Mgi Jnum  J:7596
Mgi Id  MGI:56065 Doi  10.1038/311344a0
Citation  Siu G, et al. (1984) The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature 311(5984):344-50
abstractText  It has been postulated that the variable region of the beta-polypeptide of the murine T-cell antigen receptor is encoded by three distinct germ-line gene segments--variable (V beta), diversity (D beta) and joining (J beta)--that are rearranged to generate a V beta gene. Germ-line V beta and J beta gene segments have been isolated previously. Here we report the isolation and characterization of two germ-line D beta gene segments that have recognition signals for DNA rearrangement strikingly similar to those found in the three immunoglobulin gene families and in V beta and J beta gene segments. The D beta and J beta segments can join in the absence of V beta gene segment rearrangement and these rearranged sequences are transcribed in some T cells.
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