First Author | Siu G | Year | 1984 |
Journal | Nature | Volume | 311 |
Issue | 5984 | Pages | 344-50 |
PubMed ID | 6090932 | Mgi Jnum | J:7596 |
Mgi Id | MGI:56065 | Doi | 10.1038/311344a0 |
Citation | Siu G, et al. (1984) The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature 311(5984):344-50 |
abstractText | It has been postulated that the variable region of the beta-polypeptide of the murine T-cell antigen receptor is encoded by three distinct germ-line gene segments--variable (V beta), diversity (D beta) and joining (J beta)--that are rearranged to generate a V beta gene. Germ-line V beta and J beta gene segments have been isolated previously. Here we report the isolation and characterization of two germ-line D beta gene segments that have recognition signals for DNA rearrangement strikingly similar to those found in the three immunoglobulin gene families and in V beta and J beta gene segments. The D beta and J beta segments can join in the absence of V beta gene segment rearrangement and these rearranged sequences are transcribed in some T cells. |