| First Author | Derynck R | Year | 1988 |
| Journal | EMBO J | Volume | 7 |
| Issue | 12 | Pages | 3737-43 |
| PubMed ID | 3208746 | Mgi Jnum | J:32381 |
| Mgi Id | MGI:79879 | Doi | 10.1002/j.1460-2075.1988.tb03257.x |
| Citation | Derynck R, et al. (1988) A new type of transforming growth factor-beta, TGF-beta 3. EMBO J 7(12):3737-43 |
| abstractText | A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta. |
