| First Author | Kasahara M | Year | 1990 |
| Journal | Genomics | Volume | 8 |
| Issue | 1 | Pages | 90-6 |
| PubMed ID | 1981995 | Mgi Jnum | J:11090 |
| Mgi Id | MGI:59532 | Doi | 10.1016/0888-7543(90)90229-n |
| Citation | Kasahara M, et al. (1990) Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to the vicinity of the d locus on mouse chromosome 9. Genomics 8(1):90-6 |
| abstractText | Recombinant inbred strains of mice were used to localize the genes coding for the class alpha glutathione S-transferase 2 (Gst-2). The genes showed three distinct strain distribution patterns, indicating that they occur in at least three clusters separable by recombination. All three clusters are located in the vicinity of the d locus on mouse chromosome 9, but two of them are closer to d than the third. Linked to Gst-2 on mouse chromosome 9 are two enzyme-encoding loci, Pgm-3 and Mod-1. The human counterparts of Gst-2, Pgm-3, and Mod-1 map to 6p12, 6q12, and 6q12, respectively. Thus, the pericentric region of human chromosome 6 has its homolog in the segment spanning Gst-2, Pgm-3, and Mod-1 on mouse chromosome 9. The fact that the syntenic group extends across the centromere of human chromosome 6 can best be explained by a pericentric inversion postulated to have taken place in the primate lineage leading to Catarhini. |
