| First Author | Lusis AJ | Year | 1975 |
| Journal | Cell | Volume | 6 |
| Issue | 3 | Pages | 371-8 |
| PubMed ID | 212204 | Mgi Jnum | J:6038 |
| Mgi Id | MGI:54515 | Doi | 10.1016/0092-8674(75)90186-5 |
| Citation | Lusis AJ, et al. (1975) Genetic determination of the alpha-galactosidase developmental program in mice. Cell 6(3):371-8 |
| abstractText | The expression of alpha-galactosidase in liver, heart, and brain during postembryonic development has been examined in several inbred mouse strains. In most strains, the developmental patterns of alpha-galactosidase are coordinate with those of two other acid hydrolases, beta-glucuronidase and beta-galactosidase. Certain inbred mouse strains, including members of the C57-C58 family, have a tissue-specific alteration in the temporal expression of alpha-galactosidase activity. This alteration shows additive inheritance and appears to be controlled by a single genetic locus. The altered developmental expression of the enzyme is not accompanied by any discernible change in its physical properties. |
