| First Author | Brown WR | Year | 1989 |
| Journal | Mech Ageing Dev | Volume | 49 |
| Issue | 2 | Pages | 137-46 |
| PubMed ID | 2529401 | Mgi Jnum | J:22710 |
| Mgi Id | MGI:70569 | Doi | 10.1016/0047-6374(89)90097-3 |
| Citation | Brown WR, et al. (1989) Age-related changes in contact photosensitivity differ among mouse strains. Mech Ageing Dev 49(2):137-46 |
| abstractText | There are differences among mouse strains in the age-related changes in reactivity to the contact photosensitizer tetrachlorosalicylanilide (TCSA). We found a tendency to lower reactions in older mice, with some strains showing declines from an early age (BALB/cJ, MRL/MpJ +/+, MRL/MpJ lpr/lpr and SJL/J). Others had increasing reactions until about 30-50 weeks of age before declining (DBA/1J, C3H/HeJ, and A/J) and one strain (C57BL/6J) had increased reactivity with age. There are also differences in the role of cyclophosphamide-sensitive T-suppressor cells in these age-related changes. In some mouse strains, BALB/cJ, C57BL/6J, A/J, DBA/1J and C3H/HeJ, age-related changes in reactivity to TCSA are independent of changes in cyclophosphamide-sensitive suppressor cells. In other strains, MRL/MpJ +/+, MRL/MpJ lpr/lpr and SJL/J, the development of cyclophosphamide-sensitive suppressor cells is responsible for the initial, though not later, stages of the age-related decline in reactivity. |
