| First Author | Smith DF | Year | 1988 |
| Journal | Psychopharmacology (Berl) | Volume | 94 |
| Issue | 3 | Pages | 428-30 |
| PubMed ID | 3128821 | Mgi Jnum | J:27943 |
| Mgi Id | MGI:75577 | Doi | 10.1007/BF00174702 |
| Citation | Smith DF (1988) Lithium attenuates clonidine-induced hypoactivity: further studies in inbred mouse strains. Psychopharmacology (Berl) 94(3):428-30 |
| abstractText | Four strains of mice (C57, BALB, DBA, C3H) were used to determine whether genetic factors influence the effects of lithium on hypoactivity induced by a low dose of the alpha 2-adrenoceptor agonist clonidine (0.2 mg/kg). Lithium was administered in the diet for 3-4 weeks at a dosage that produced average serum lithium levels of 0.58-0.66 mmol/l. Locomotor activity was reduced by either clonidine or by lithium given alone. When combined, however, lithium attenuated the activity-suppressant effects of clonidine, and that action was influenced by genetic factors. The findings suggest that genetic differences in alpha 2-adrenoceptors play a role in behavioural effects of lithium. |
