| First Author | Jiang H | Year | 1992 |
| Journal | Science | Volume | 256 |
| Issue | 5060 | Pages | 1213-5 |
| PubMed ID | 1375398 | Mgi Jnum | J:1027 |
| Mgi Id | MGI:49559 | Doi | 10.1126/science.256.5060.1213 |
| Citation | Jiang H, et al. (1992) Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science 256(5060):1213-5 |
| abstractText | The course of experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis, is affected by immunoregulatory T lymphocytes. When animals are immunized with encephalitogenic peptide of myelin basic protein and recover from the first episode of EAE, they become resistant to a second induction of this disease. Animals depleted of CD8+ T cells by antibody-mediated clearance were used to examine the role of CD8+ T cells in EAE. These cells were found to be major participants in the resistance to a second induction of EAE but were not essential for spontaneous recovery from the first episode of the disease. |
