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Publication : Regional assignment of the mouse alpha A2-crystallin gene (Crya-1) to chromosome 17A3----B by in situ hybridization.

First Author  Kaye NW Year  1990
Journal  Cytogenet Cell Genet Volume  53
Issue  2-3 Pages  95-6
PubMed ID  2369847 Mgi Jnum  J:10626
Mgi Id  MGI:59074 Doi  10.1159/000132903
Citation  Kaye NW, et al. (1990) Regional assignment of the mouse alpha A2-crystallin gene (Crya-1) to chromosome 17A3----B by in situ hybridization. Cytogenet Cell Genet 53(2-3):95-6
abstractText  Previously, we assigned the alpha A2-crystallin (Crya-1) structural gene to mouse chromosome 17 via Southern blot hybridization analysis of mouse x Chinese hamster somatic cell hybrids. Using in situ hybridization, we have now localized this gene to 17A3----B, a subchromosomal region containing several genes whose linkage relationships have been shown to be conserved on human chromosome 6. In man, however, the homologous gene (CRYA1) is located on human chromosome 21, indicating that internal rearrangements can occur within highly conserved chromosomal regions during the divergence of man and mouse.
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