First Author | Chen J | Year | 1992 |
Journal | Mol Immunol | Volume | 29 |
Issue | 9 | Pages | 1121-9 |
PubMed ID | 1379680 | Mgi Jnum | J:1672 |
Mgi Id | MGI:50198 | Doi | 10.1016/0161-5890(92)90045-y |
Citation | Chen J, et al. (1992) Variable region cDNA sequences of three mouse monoclonal anti-idiotypic antibodies specific for anti-alpha(1----6)dextrans with groove- or cavity-type combining sites. Mol Immunol 29(9):1121-9 |
abstractText | The variables regions of three syngeneic anti-idiotypic antibodies (Ab2s) were cloned and sequenced. They are encoded by different VL genes, two are from different members of V kappa-Ox1 superfamily. The H chains are encoded by VH genes belonging to three different VH families, J558, Q52 and 7183. Together with a previous report from this laboratory, the nucleotide sequences of four Ab2s to anti-alpha(1----6)dextrans have been presented. They are derived from a number of unrelated germline genes, and differ from similar studies in anti-NP, anti-GAT and anti-Ars systems. Three of four Ab2s in the anti-alpha(1----6)dextran system appear to have D-D fusions, which has also been reported in several other Ab2s. |