| First Author | Shivers BD | Year | 1989 |
| Journal | Neuron | Volume | 3 |
| Issue | 3 | Pages | 327-37 |
| PubMed ID | 2561970 | Mgi Jnum | J:10726 |
| Mgi Id | MGI:59172 | Doi | 10.1016/0896-6273(89)90257-2 |
| Citation | Shivers BD, et al. (1989) Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Neuron 3(3):327-37 |
| abstractText | Two cDNAs encoding novel GABAA receptor subunits were isolated from a rat brain library. These subunits, gamma 2 and delta, share approximately 35% sequence identity with alpha and beta subunits and form functional GABA-gated chloride channels when expressed alone in vitro. The gamma 2 subunit is the rat homolog of the human gamma 2 subunit recently shown to be important for benzodiazepine pharmacology. Cellular localization of the mRNAs encoding the gamma 2 and delta subunits in rat brain revealed that largely distinct neuronal subpopulations express the two subunits. The delta subunit distribution resembles that of the high affinity GABAA receptor labeled with [3H]muscimol; the gamma 2 subunit distribution resembles that of GABAA/benzodiazepine receptors labeled with [3H]flunitrazepam. These findings have implications for the composition of two different GABAA receptor subtypes and for information processing in networks using GABA for signaling. |
