| First Author | Ragoussis J | Year | 1992 |
| Journal | Genomics | Volume | 14 |
| Issue | 3 | Pages | 673-9 |
| PubMed ID | 1427894 | Mgi Jnum | J:3067 |
| Mgi Id | MGI:51582 | Doi | 10.1016/s0888-7543(05)80167-3 |
| Citation | Ragoussis J, et al. (1992) A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. Genomics 14(3):673-9 |
| abstractText | A novel testis-expressed Zn finger gene (ZNF76) was identified by screening cDNA libraries with cosmids derived from 6p21. ZNF76 is a member of the GLI-Kruppel family of DNA binding proteins. It is conserved in mouse where transcription in testis is initiated at Day 20 after birth. The mouse tcp-11 gene is located in the distal inversion of the t-complex and is developmentally regulated in the same manner as ZNF76. The human homolog of tcp-11 was isolated to allow a precise chromosomal localization. By using a combination of somatic cell hybrids, radiation hybrids, metaphase and interphase fluorescent in situ hybridization, and pulsed-field gel electrophoresis, we mapped the two genes to the 6p21.2 to 6p21.3 region and linked them to each other within 300 kb of DNA, approximately 2 Mb centromeric to the major histocompatibility complex. |
