| First Author | Tucker PK | Year | 1992 |
| Journal | Mamm Genome | Volume | 3 |
| Issue | 1 | Pages | 28-35 |
| PubMed ID | 1581630 | Mgi Jnum | J:524 |
| Mgi Id | MGI:49061 | Doi | 10.1007/BF00355838 |
| Citation | Tucker PK, et al. (1992) A mouse Y chromosome pseudogene is related to human ubiquitin activating enzyme E1. Mamm Genome 3(1):28-35 |
| abstractText | A 2041 bp DNA fragment isolated from the Sxr (sex reversed) region of the mouse Y Chromosome (Chr) was sequenced and characterized. The sequence, pY8/b, contains four exons that are highly similar to 525 contiguous bases from the cDNA of human ubiquitin activating enzyme E1. Two of the exons contain stop codons, indicating that pY8/b is not part of a functional gene. Sequences related to pY8/b were amplified from the Y Chr of the inbred mouse strain, C57BL/6J. These sequences may be portions of the recently discovered functional equivalent of pY8/b. Despite a high degree of similarity with the human E1 gene, the functional equivalent of pY8/b is not the mouse E1 gene, because unlike E1, the functional equivalent of pY8/b is expressed in a tissue-specific manner. These data are discussed with respect to theory on the evolution of the mammalian Y Chr, and in particular, to the prediction that functional genes on the Y Chr have a male-specific function. |
