| First Author | Pavone F | Year | 1992 |
| Journal | Brain Res | Volume | 577 |
| Issue | 2 | Pages | 347-50 |
| PubMed ID | 1606505 | Mgi Jnum | J:782 |
| Mgi Id | MGI:49316 | Doi | 10.1016/0006-8993(92)90296-l |
| Citation | Pavone F, et al. (1992) Serotonergic influence on cholinergic-induced analgesia: differences in two inbred strains of mice. Brain Res 577(2):347-50 |
| abstractText | C57BL/6 (C57) and DBA/2 (DBA) inbred mice showed different analgesic responses to cholinergic stimulation. The simultaneous administration of muscarinic and serotonergic agonists, oxotremorine and 5-methoxy-NN-dimethyltryptamine (5-MeODMT), lowered the antinociceptive effect of the cholinergic drug in DBA mice, while no effects were detectable in the C57 strain. These results suggest a strain-dependent behavioural effect of the interaction of cholinergic and serotonergic neuronal systems. |
