| First Author | McNamara JO | Year | 1992 |
| Journal | J Neurosci | Volume | 12 |
| Issue | 7 | Pages | 2555-62 |
| PubMed ID | 1319477 | Mgi Jnum | J:1382 |
| Mgi Id | MGI:49909 | Doi | 10.1523/JNEUROSCI.12-07-02555.1992 |
| Citation | McNamara JO, et al. (1992) Chromosomal localization of human glutamate receptor genes. J Neurosci 12(7):2555-62 |
| abstractText | The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR 1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22-23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral-renal syndrome of Lowe and a form of manic-depressive illness. |
