| First Author | Eccles MR | Year | 1991 |
| Journal | Gene | Volume | 108 |
| Issue | 2 | Pages | 285-8 |
| PubMed ID | 1660841 | Mgi Jnum | J:2592 |
| Mgi Id | MGI:51114 | Doi | 10.1016/0378-1119(91)90447-j |
| Citation | Eccles MR (1991) Genes encoding the platelet-derived growth factor (PDGF) receptor and colony-stimulating factor 1 (CSF-1) receptor are physically associated in mice as in humans. Gene 108(2):285-8 |
| abstractText | The BALB/c mouse DNA was analyzed by field-inversion gel electrophoresis to determine the orientation and distance between the beta-platelet-derived growth factor receptor-encoding gene (Pdgfr) and the colony-stimulating factor 1 receptor-encoding gene (Csfmr). It was found that the 5' portion of the Pdgfr gene was cleaved by the enzyme ClaI into two fragments. The 425-kb fragment hybridized with a 3' Pdgfr and a 5' Csfmr probe. This result shows that the Csfmr gene is 3' relative to the Pdgfr gene, and suggests that the Pdgfr and Csfmr genes are physically linked. |
