| First Author | Miles JS | Year | 1991 |
| Journal | Genomics | Volume | 11 |
| Issue | 2 | Pages | 309-16 |
| PubMed ID | 1685137 | Mgi Jnum | J:2273 |
| Mgi Id | MGI:50797 | Doi | 10.1016/0888-7543(91)90137-4 |
| Citation | Miles JS, et al. (1991) Mapping genes encoding drug-metabolizing enzymes in recombinant inbred mice. Genomics 11(2):309-16 |
| abstractText | Probes for cytochrome P450IVA (P450IVA), alpha- and pi-class glutathione S-transferases (GST), and phenol-metabolizing UDP-glucuronyltransferase (UDPGT-K39) detected restriction fragment length variants (RFLVs) between C57BL/6J and DBA/2J mice. These variants were used to map the P450IVA genes (Cyp4 alpha) to chromosome 4, close to Mtv-13 and Pmv-19, midway between brown (b) and Gpd-1; GST alpha genes were mapped to chromosome 9, with a cross-hybridizing sequence mapping to another chromosome; the GST pi genes were mapped to the distal end of chromosome 1 near Pmv-21; one UDPGT-K39 variant to chromosome 1, between Acrg and Emv-17, and another showed linkage to Odc-10 on an unidentified chromosome. No RFLVs were detected with probes for P450IID, P450 reductase, androsterone-metabolizing UDPGT, GST mu, or microsomal GST. |
