| First Author | Cieutat AM | Year | 1993 |
| Journal | Biochem Biophys Res Commun | Volume | 193 |
| Issue | 2 | Pages | 771-8 |
| PubMed ID | 8512576 | Mgi Jnum | J:12599 |
| Mgi Id | MGI:60840 | Doi | 10.1006/bbrc.1993.1692 |
| Citation | Cieutat AM, et al. (1993) A comparative analysis of cDNA-derived sequences for rat and mouse beta 3 integrins (GPIIIA) with their human counterpart. Biochem Biophys Res Commun 193(2):771-8 |
| abstractText | Alpha IIb beta 3 (GPIIb-IIIa), the platelet receptor for fibrinogen, is a member of the integrin superfamily. We have now cloned the mouse and rat beta 3 cDNAs. These data represent the first available non-human beta 3 sequences, allowing important comparative analyses. Both beta 3 sequences are highly homologous with human beta 3, well above average rodent-human protein homology of 79%. The ligand binding domains (aa) 109-171 and 204-229) are, respectively, 90% and 100% homologous. The beta 3 transmembrane and the cytoplasmic tail are surprisingly highly conserved, being 97% and 100% homologous, respectively, but share little homology with beta 1, or beta 2. This latter difference argues strongly in favor for a crucial beta 3-specific function for these domains. In conclusion, we present the first comparative analysis of beta 3 chains and demonstrate high overall homology. The biological implications of these comparisons are discussed. |
