| First Author | Malley A | Year | 1993 |
| Journal | Transplantation | Volume | 56 |
| Issue | 4 | Pages | 922-7 |
| PubMed ID | 8212218 | Mgi Jnum | J:15749 |
| Mgi Id | MGI:63863 | Doi | 10.1097/00007890-199310000-00028 |
| Citation | Malley A, et al. (1993) H-2-specific T suppressor cells. I. Evidence for T suppressor inducer and effector molecules in suppression. Transplantation 56(4):922-7 |
| abstractText | The induction of H-2-specific Ts cells was accomplished by the i.v. injection of X-irradiated (2000R) C57BL/6 spleen cells into CBA/J mice. These Ts cells significantly (78%) suppressed the delayed type hypersensitivity (DTH) response in CBA/J mice injected s.c. with X-irradiated (2000R) C57BL/6 spleen cells and given a footpad challenge with the same cell population 5 days later. We have shown that both CD4 and CD8 T cells were involved in the observed suppression, and these cells secrete T suppressor inducer (Tsfi) and T suppressor effector (Tsfe) molecules. Both Tsfi and Tsfe molecules were shown to significantly inhibit (> 87%) one-way mixed lymphocyte responses between CBA/J and mitomycin C-treated C57BL/6 spleen cells. Using an adoptive transfer method, we showed that mice given both a primary and secondary immunization with X-irradiated C57BL/6 spleen cells to induce H-2-specific Ts cells contain a significantly greater number of Ts cells than mice given only a primary immunization, suggesting the presence of memory Ts cells. |
