| First Author | Larsen CP | Year | 1992 |
| Journal | J Exp Med | Volume | 176 |
| Issue | 4 | Pages | 1215-20 |
| PubMed ID | 1328465 | Mgi Jnum | J:2515 |
| Mgi Id | MGI:51038 | Doi | 10.1084/jem.176.4.1215 |
| Citation | Larsen CP, et al. (1992) Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations. J Exp Med 176(4):1215-20 |
| abstractText | Whereas dendritic cells (DC) are known to be potent activators of T cells both in vitro and in vivo, the critical costimulatory molecules expressed on DC are not well characterized. Using immunocytochemical and molecular techniques we find that splenic DC express B7/BB1, the counter-receptor for CD28. Moreover, expression of B7/BB1 is upregulated on epidermal Langerhans cells (LC) during their functional maturation into potent T cell stimulators. In blocking experiments, we find that participation of B7/BB1 is required for optimal proliferation of unprimed, allogeneic T cells in DC-driven, primary mixed leukocyte reactions. These data demonstrate that the regulated expression of B7/BB1 on DC may be important in the initiation of a primary T cell response. |
