| First Author | Leiter EH | Year | 1992 |
| Journal | Reg Immunol | Volume | 4 |
| Issue | 5 | Pages | 263-73 |
| PubMed ID | 1290746 | Mgi Jnum | J:4138 |
| Mgi Id | MGI:52639 | Citation | Leiter EH, et al. (1992) Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice. Reg Immunol 4(5):263-73 |
| abstractText | Genetically-controlled defects in the development and function of antigen presenting cells may explain why NOD mice exhibit an impaired ability to induce tolerance and/or activate immunoregulatory T cells. These defects provide understanding for why diabetogenesis in NOD mice is so sensitive to immunomodulatory changes mediated through the environment. Although the unique MHC haplotype of NOD mice is clearly a major contributor to diabetes susceptibility, evidence for a complex interaction between MHC loci and many other polygenetic factors is reviewed. |
