| First Author | Emi M | Year | 1993 |
| Journal | Nat Genet | Volume | 5 |
| Issue | 2 | Pages | 151-7 |
| PubMed ID | 8252040 | Mgi Jnum | J:59621 |
| Mgi Id | MGI:1351975 | Doi | 10.1038/ng1093-151 |
| Citation | Emi M, et al. (1993) A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers. Nat Genet 5(2):151-7 |
| abstractText | From chromosomal region 17q21.3, where a tumour suppressor gene(s) for breast and ovarian cancers is thought to be present, we have isolated a novel gene from a cosmid clone that revealed somatic rearrangements in two breast cancers. The gene (MDC) encodes a 524-amino acid metalloprotease-like, disintegrin-like and cysteine-rich protein with sequence similarity to members of the snake-venom metalloprotease/disintegrin family and guinea-pig sperm-surface protein PH-30. These proteins have been implicated in cell-cell or cell-extracellular matrix interactions. Rearrangements in both tumours involve multiple exons and disrupt the coding region of the new MDC. |
