First Author | Avraham KB | Year | 1993 |
Journal | Genomics | Volume | 18 |
Issue | 1 | Pages | 131-3 |
PubMed ID | 8276397 | Mgi Jnum | J:15133 |
Mgi Id | MGI:63270 | Doi | 10.1006/geno.1993.1436 |
Citation | Avraham KB, et al. (1993) Murine chromosomal location of four class III POU transcription factors. Genomics 18(1):131-3 |
abstractText | A family of mouse genes encoding class III POU transcription factors consists of four members: Oct-6, Brn-2, Brn-1, and Brn-4. In accordance with mouse nomenclature, these loci have been designated Otf-6, Otf-7, Otf-8, and Otf-9, respectively. While the four genes share a highly conserved class III POU domain, the remaining regions are considerably diverged from each other. The POU domains of these transcription factors recognize the octamer-motif sequence and possess a similar DNA-binding specificity. Chromosomal mapping has demonstrated that the four genes are unlinked: Otf-6 is located on the distal region of chromosome 4, Otf-7 on the proximal region of chromosome 4, Otf-8 on chromosome 1, and Otf-9 on the X chromosome. |