| First Author | Vignaux F | Year | 1994 |
| Journal | Eur J Immunol | Volume | 24 |
| Issue | 4 | Pages | 923-7 |
| PubMed ID | 7512034 | Mgi Jnum | J:17697 |
| Mgi Id | MGI:65728 | Doi | 10.1002/eji.1830240421 |
| Citation | Vignaux F, et al. (1994) Fas-based lymphocyte-mediated cytotoxicity against syngeneic activated lymphocytes: a regulatory pathway?. Eur J Immunol 24(4):923-7 |
| abstractText | To investigate the possibility that Fas-based immune regulation and Fas-based T cell-mediated cytotoxicity (F-CMC) are causally related, we explored the latter in activated lymphocyte populations. These were shown to contain effector cells exerting cytotoxicity via an F-CMC mechanism which could be differentially triggered by PMA and ionomycin. F-CMC operated in trans, requiring an lpr (Fas) product on target cells and a gld product on effector cells. Activated lymphocyte populations were also shown to contain F-CMC target cells. Activated lymphocyte populations thus contained both effector and target F-CMC cells, which could lyse each other. Fas-based cytotoxicity can thus lead to the lysis of syngeneic activated lymphocytes, consistent with the possibility of its participation in the down-regulation of immune responses, and more generally offering a model of socially controlled, direct membrane-mediated cell death. |
